Which of the following methods have been used to generate libraries of disrupted genes for an organism? Please select all that apply.

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Targeted insertion and RNAi have both been used to generate libraries in which all the genes in an organism have been disrupted or their effects down-regulated, respectively. CRISPR is another technique that is likely to be very useful in generating mutant libraries in the near future. Cytogenetics is the study of inheritance as it relates to chromosomes. Promoter trapping is a technique where a visible marker is used to find out when and where a promoter is active.

Which of the Following Methods Have Been Used to Generate