Question 1

Which of the following tests may be used to monitor liver function?

Accepted Answer

PT is used to measure the production of clotting factors by the liver. Troponin 1 elevates within 3-12 hours after MI. BNP is a peptide released in response to myocardial stretch and is used to monitor heart failure.T4 monitors thyroid function.

Question 2

Concerning schizophrenia and bipolar disorder, which of the following statements is false?

Accepted Answer

Lithium is a first-line treatment option for bipolar disorder as is valproate, aripiprazole, quetiapine, risperidone, carbamazepine, and others. The other statements are true regarding bipolar disorder and schizophrenia.

Question 3

What do IND and NDA stand for respectively?

Accepted Answer

IND and NDA are acronyms for "Investigation New Drug and "New Drug Application" respectively.

Question 4

Which of the following dosage forms would be the best option to avoid first-pass metabolism?

Accepted Answer

One can avoid first-pass metabolism by avoiding the GI tract. The only dosage form listed that avoids the GI tract is a transdermal patch.

Question 5

Which of the following is a symptom/sign of pericardial effusion?
I. Tachycardia
II. Muffled heart sounds
III. Jugular vein distention
IV. Cyanosis

Accepted Answer

All the signs and symptoms listed are correct for pericardial effusion, or the build-up of fluids in the sac surrounding the heart. Many chemotherapeutic drugs such as cytarabine, 5FU, cyclophosphamide, and doxorubicin can cause pericardial effusion.

Question 6

Which of the following chemical modifications would likely increase the water solubility of a drug?

Accepted Answer

Amorphous forms have greater solubility than crystalline forms. Anhydrous (without water) compounds have greater solubility than when they become hydrated. Lipophilic indicates "fat-loving," so a lipophilic side group would decrease solubility as would the removal of a hydroxyl (-OH) group.

Question 7

Which of the following are not signs/symptoms/complications of lupus-like syndrome?

Accepted Answer

Lupus-like syndrome is a reaction to drug therapy that is characterized by a red, scaly, macular rash, joint pain, and fever. Arrhythmias are not a characteristic of lupus-like syndrome.

Question 8

Which of the following is not considered a sign of a stroke?

Accepted Answer

Sudden seizures are not considered to be a sign of a stroke. All the other signs listed are potential signs of a stroke.

Question 9

Which of the following are not signs/symptoms of pseudomembranous colitis?

Accepted Answer

Constipation does not generally occur in pseudomembranous colitis. The major sign/symptom is diarrhea with blood and mucus in the stool.

Quiz 1: Biomedical