Nitrate tolerance is least likely to develop with the use of:

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Nitrate tolerance is least likely to develop with the use of sublingual glyceryl trinitrate because it is used intermittently, usually only when needed for acute relief of angina symptoms, allowing the body to maintain sensitivity to nitrates. Continuous or long-term nitrate exposure, as seen with sustained release or transdermal formulations, is more likely to lead to tolerance.

Nitrate Tolerance Is Least Likely to Develop with the Use