Question 1

2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of

Accepted Answer

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide is the IUPAC name for Lignocaine, also known as Lidocaine, a common local anesthetic and antiarrhythmic drug.

Question 2

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:

Accepted Answer

Isosorbide mononitrate undergoes minimal first-pass metabolism in the liver, making it more bioavailable than other organic nitrates.

Question 3

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:

Accepted Answer

Glyceryl trinitrate primarily benefits patients with classical angina pectoris by reducing cardiac preload. This is achieved through venodilation, which decreases the volume of blood returning to the heart, thereby reducing the heart's workload and oxygen demand.

Question 4

Organic nitrates relax vascular smooth muscle by:

Accepted Answer

Organic nitrates relax vascular smooth muscle primarily by increasing intracellular cyclic GMP. This is achieved through the release of nitric oxide (NO), which then stimulates the production of cyclic GMP, leading to vasodilation.

Question 5

Nitrate tolerance is least likely to develop with the use of:

Accepted Answer

Nitrate tolerance is least likely to develop with the use of sublingual glyceryl trinitrate because it is used intermittently, usually only when needed for acute relief of angina symptoms, allowing the body to maintain sensitivity to nitrates. Continuous or long-term nitrate exposure, as seen with sustained release or transdermal formulations, is more likely to lead to tolerance.

Quiz 1: Cardiovascular Drugs

2-(diethylamino) -N-(2,6-dimethylphenyl) Acetamide is IUPAC name of

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:

Organic nitrates relax vascular smooth muscle by:

Nitrate tolerance is least likely to develop with the use of: