Question 1

Which of the following is true for monolithic devices?

Accepted Answer

C

Question 2

The duration of action of parental controlled release systems can be extended up to what time?

Accepted Answer

Parenteral controlled release systems are designed to release drugs at a controlled rate over an extended period, which can range from a day to a week, a month, and even up to a year, depending on the formulation and mechanism of the drug delivery system.

Question 3

What is the drawback of parental controlled release systems?

Accepted Answer

The main drawback of parental controlled release systems is that once the drug is administered, it cannot be easily removed, which can be problematic if there are adverse reactions or if the dosage needs to be adjusted.

Question 4

Which one of the following should not be a characteristic of the vehicles or polymers which are used for parenteral formulations?

Accepted Answer

Vehicles or polymers used for parenteral formulations must be sterile, nonirritating, and often biodegradable, but they should not contain pyrogens, which are substances that can cause fever when introduced into the body.

Question 5

With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling?

Accepted Answer

Increasing the pH to make a solution highly basic does not directly control drug release in aqueous solutions. Drug release can be controlled by modifying the drug's environment or characteristics, such as increasing viscosity, forming complexes, or reducing solubility, but simply making the solution more basic does not inherently control the release of the drug.

Question 6

Release of water-soluble drugs can be retarded by presenting it as ____________ suspension

Accepted Answer

Oil suspensions can retard the release of water-soluble drugs because the oil phase can act as a barrier to the dissolution and diffusion of the drug into the surrounding aqueous environment, slowing down its release rate.

Question 7

Larger particle size leads to ____________ dissolution

Accepted Answer

Larger particle size leads to slower dissolution because there is less surface area for the solvent to act on, slowing down the rate at which the particles dissolve.

Question 8

Which of the following is a characteristic of microspheres?

Accepted Answer

Microspheres are free flowing powders that are used to control drug release by partitioning the drug from the oil.

Question 9

Which of the following is a characteristic of oil solutions?

Accepted Answer

Oil solutions can control drug release by partitioning the drug from the oil phase to the target site, which is a mechanism to modulate the drug's bioavailability and effectiveness.

Question 10

Which of the following is a characteristic of aqueous solutions?

Accepted Answer

Drug release can be increased by increasing viscosity in aqueous solutions.

Question 11

Which of the following is a characteristic of nanoparticles?

Accepted Answer

Nanoparticles are defined by their size, which ranges from 10 to 100 nanometers. This small size gives them unique properties compared to their bulk counterparts.

Question 12

Which of the following is a characteristic of the parental controlled drug release system by liposomes?

Accepted Answer

Liposomes are characterized by a lipid bilayer that encloses the drug, allowing for controlled release and targeted delivery.

Question 13

Which of the following can be incorporated into a liposome?

Accepted Answer

Liposomes can encapsulate a wide range of substances including drugs, peptides, viruses, and bacteria due to their versatile and biocompatible nature, allowing for diverse applications in drug delivery and vaccine development.

Question 14

Which of the following is a characteristic of resealed erythrocytes?

Accepted Answer

Resealed erythrocytes are nonimmunogenic because they are the patient's own cells that have been modified and reintroduced, thus avoiding immune system recognition and response.

Question 15

Which of the following statement is false for osmotic pumps?

Accepted Answer

The answer of Which of the following statement is false...

Question 16

Which of the following statement is true for osmotic pumps?

Accepted Answer

The answer of Which of the following statement is true...

Question 17

Which of the following should not be a property of implants?

Accepted Answer

Implants should be environmentally stable, biostable, and non-toxic to ensure they do not harm the body and can last for the intended duration of their use. However, being nonremovable is not a necessary property for all implants, as some may need to be removed or replaced over time.

Question 18

Which is the disadvantage for implants?

Accepted Answer

Implants require a minor surgical procedure for their insertion and removal, which is considered a disadvantage compared to other forms of medication that do not require such procedures.

Question 19

Subcutaneous tissue is an ideal location for implants?

Accepted Answer

Subcutaneous tissue is often chosen for implants due to its ease of access, sufficient space for implant placement, and relatively low risk of complications, making it an ideal location for various types of implants.

Question 20

Which of the following drugs are used in implants?

Accepted Answer

Morphine antagonists, such as naltrexone, can be used in implant form for the treatment of opioid dependence, providing a long-term release of medication to block the effects of opioids.

Quiz 3: Characteristics and Applications of Controlled Drug Release Systems