Question 1

Which of the following drugs can not be given as transdermal administration?
A)Drugs with very short half life
B)Drugs with narrow therapeutic index
C)Easy removal and termination
D)Drug against peptic ulcer

Accepted Answer

Transdermal administration is not suitable for drugs against peptic ulcers because these drugs typically need to act directly on the stomach lining, which cannot be achieved through skin absorption.

Question 2

What are the characteristics of the monolithic devices?
A)The drug has a large therapeutic index
B)Aqueous solution
C)Control drug release by partitioning the drug from oil
D)Administration of emulsion

Accepted Answer

Monolithic devices typically involve drugs with a large therapeutic index, which allows for a wider safety margin in dosing.

Question 3

Which of the following characteristics is suitable for transdermal drug?
A)Large drug dose
B)Large molecular size
C)Drugs with narrow therapeutic index
D)Drug which are metabolized in the skin

Accepted Answer

Drugs with a narrow therapeutic index are suitable for transdermal delivery because this method allows for controlled, steady absorption of the drug, minimizing the risk of fluctuating blood levels that could lead to toxicity or subtherapeutic effects.

Question 4

The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.
A)Square of time
B)The square root of time
C)Twice the time
D)Half the time

Accepted Answer

The rate at which monolithic devices transfer drug to the patient's body is proportional to the square root of time. This is a characteristic of Fickian diffusion, a common mechanism in controlled drug delivery systems.

Question 5

What are the characteristics of the reservoir or membrane devices?
A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)Control drug release by partitioning the drug from oil
D)Administration of emulsion

Accepted Answer

The answer of What are the characteristics of the reservoir...

Question 6

What are the characteristics of the mixed monolithic reservoir devices?
A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)The drug polymer matrix is layered by rate controlling membrane
D)Administration of emulsion

Accepted Answer

The characteristic of mixed monolithic reservoir devices is that the drug polymer matrix is layered by a rate controlling membrane, which controls the rate at which the drug is released from the device.

Question 7

Which of the following is false in regarding reservoir devices?
A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for low therapeutic index
D)The drug is contained in a powder from floating on liquid

Accepted Answer

The answer of Which of the following is false in...

Question 8

Which of the following is true for monolithic devices?
A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for drugs with large therapeutic index
D)The drug is contained in a powder form floating on liquid

Accepted Answer

The answer of Which of the following is true for...

Question 9

The absorption of the ophthalmic drug does not depend on which of the following?
A)Physicochemical properties of permeating molecule
B)Drainage of tears
C)Output of tears
D)Size of the eyeball

Accepted Answer

The absorption of ophthalmic drugs is influenced by the physicochemical properties of the drug, tear drainage, and tear production. However, the size of the eyeball does not directly affect drug absorption.

Question 10

Which of the following is false for monolithic devices?
A)The drug used for these devices has large therapeutic index
B)There are three categories of matrix devices
C)1st type has the drug dissolved in the polymer matrix
D)2nd type has drug delivery

Accepted Answer

Monolithic devices typically refer to a single-phase system where the drug is uniformly dispersed throughout the polymer matrix, and there are not specifically three categories of matrix devices as implied by option B. The classification of monolithic devices can vary based on different criteria such as the mechanism of drug release (diffusion, degradation, swelling, etc.) rather than being limited to three distinct categories.

Question 11

Problems with opioid TDDS include.
A)Poor patient compliance
B)Allergy
C)Constipation.
D)Respiratory depression.

Accepted Answer

The answer of Problems with opioid TDDS include.
A)Poor patient compliance
B)Allergy
C)Constipation.
D)Respiratory...

Question 12

Regarding the skin:
A)The epidermis is the thickest layer.
B)The stratum corneum is the greatest barrier to transdermal transport.
C)The dermis has a rich capillary blood supply.
D)Skin hydration is a cause of inter-individual variation in drug absorption.

Accepted Answer

The answer of Regarding the skin:
A)The epidermis is the thickest...

Question 13

How much thickness of the dermis layer?
A)2 to 7 nm
B)3 to 5 nm
C)3 to 6 nm
D)5 to 8 nm

Accepted Answer

The answer of How much thickness of the dermis layer?
A)2...

Question 14

TDDS is usually only suitable for drugs of what level of potency?
A)Typically only for drugs of high potency.
B)Low potency
C)High to low potency
D)Low to high potency

Accepted Answer

Transdermal drug delivery systems (TDDS) are generally most suitable for drugs of high potency. This is because the skin acts as a significant barrier to drug penetration, so only small amounts of highly potent drugs can effectively be delivered through this route to achieve the desired therapeutic effect.

Question 15

In the use of TDDS for drug application ? size has to be considered reasonable?
A)Strip size
B)Patch size
C)Film size
D)Diskette size

Accepted Answer

Patch size is crucial in Transdermal Drug Delivery Systems (TDDS) as it directly affects the rate of drug delivery through the skin, patient comfort, and adherence to therapy.

Question 16

What is the largest organ of the body?
A)Liver
B)Lungs
C)Skin
D)Brain

Accepted Answer

The skin is the largest organ of the body, covering the entire exterior of the body and serving as the primary barrier between the body and its environment.

Question 17

Which of the following is false for Merits of the TDDS.
A)Avoidance of the First pass effect
B)A stable and controlled blood level
C)Termination at any time is conceivable
D)Skin irritation and allergic response

Accepted Answer

The statement "Skin irritation and allergic response" is not a merit of the Transdermal Drug Delivery System (TDDS); it is actually a potential drawback or limitation. The other options (A, B, C) correctly describe advantages of TDDS, such as avoiding first-pass metabolism, providing stable blood levels of the drug, and allowing for easy termination of therapy.

Question 18

How many layer are seen in monolithic TDDS design?
A)4
B)3
C)5
D)2

Accepted Answer

The answer of How many layer are seen in monolithic...

Question 19

How many layer are seen in membrane-controlled system?
A)3
B)5
C)4
D)6

Accepted Answer

The answer of How many layer are seen in membrane-controlled...

Question 20

A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.
A)Iontophoresis
B)Sonophoresis
C)Electrophoresis
D)Ion exchange

Accepted Answer

Iontophoresis is a technique that uses a small electric charge to deliver a medicine or other chemical through the skin. It essentially increases skin permeability, allowing for the delivery of substances across the skin barrier by utilizing an electric field to move charged particles.

Quiz 2: Transdermal Drug Delivery Systems TDDS and Formulations

Which of the following drugs can not be given as transdermal administration?

What are the characteristics of the monolithic devices?

Which of the following characteristics is suitable for transdermal drug?

The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.

What are the characteristics of the reservoir or membrane devices?

What are the characteristics of the mixed monolithic reservoir devices?

Which of the following is false in regarding reservoir devices?

Which of the following is true for monolithic devices?

The absorption of the ophthalmic drug does not depend on which of the following?

Which of the following is false for monolithic devices?

Problems with opioid TDDS include.

Regarding the skin:

How much thickness of the dermis layer?

TDDS is usually only suitable for drugs of what level of potency?

In the use of TDDS for drug application ? size has to be considered reasonable?

What is the largest organ of the body?

Which of the following is false for Merits of the TDDS.

How many layer are seen in monolithic TDDS design?

How many layer are seen in membrane-controlled system?

A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.