During the first half of the chymotrypsin mechanism where the acyl-enzyme intermediate is formed, what role does His play?

Name: During the first half of the chymotrypsin mechanism where the acyl-enzyme intermediate is formed, what role does His play?
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Question

Quizplus · Accepted Answer

During the formation of the acyl-enzyme intermediate, His acts first as a general base to deprotonate Ser, enhancing its nucleophilicity, and then as a general acid to donate a proton to the leaving group.

During the First Half of the Chymotrypsin Mechanism Where the Acyl-Enzyme