The Enzyme Hexokinase Catalyzes a Reaction Where Its Substrates Are

The enzyme hexokinase catalyzes a reaction where its substrates are completely sequestered from the aqueous environment allowing for interactions to occur between enzyme and substrates that would not normally occur in an aqueous environment. What term describes this type of catalysis?

A) electrostatic catalysis
B) desolvation catalysis
C) non-aqueous catalysis
D) hydrogen-bonded catalysis
E) closed-system catalysis