The Specific Three-Dimensional Shape Assumed Spontaneously by a Large, Complex

The specific three-dimensional shape assumed spontaneously by a large, complex protein is determined primarily by

A) the sequence of amino acids in its polypeptide chain(s) .
B) the hydrophobic interactions between distant amino acids.
C) the arrangement of the R-groups along its polypeptide backbone that lead to particular patterns of coiling or folding.
D) the positions of the intra- and inter-molecular cross-links that stabilise the spatial relationships among different parts of the molecule.
E) interactions between polar and non-polar regions of the molecule, stabilised by hydrogen bonding and van der Waals forces.