Match the following statements with normal-phase chromatography or reversed-phase chromatography.
1)The more polar the mobile phase, the weaker the mobile phase.
2)The more polar the mobile phase, the stronger the mobile phase.
3)The more nonpolar the mobile phase, the weaker the mobile phase.
4)The more nonpolar the mobile phase, the stronger the mobile phase.

Question

Quizplus · Accepted Answer

A mobile phase that elutes solutes from the column quickly is known as a strong mobile phase.A mobile phase that does not lead to quick elution from the column is known as a relatively weak mobile phase.In normal-phase chromatography, the stationary phase is relatively polar.When a relatively polar mobile phase is used, the polar mobile phase competes with the solute for the stationary phase, causing the solute to stay with the mobile phase longer and elute from the column quicker.Thus in normal-phase chromatography, a polar mobile phase is a strong mobile phase.A relatively nonpolar mobile phase is not going to offer much competition with the solute for the stationary phase, allowing the solute to stay on the column longer.Thus a nonpolar mobile phase is considered a weaker solvent in normal-phase chromatography.

Match the Following Statements with Normal-Phase Chromatography or Reversed-Phase Chromatography