Enzymes That Are of Diagnostic Utility Are Primarily Located ______

Enzymes that are of diagnostic utility are primarily located ______, and changes in plasma concentration of these enzymes are indicative of ______.

A) in plasma, the cause of the disease leading to the change
B) within cells, the cause of the disease leading to the change
C) in plasma, the location and nature of the pathological change
D) within cells, the location and nature of the pathological change