You are studying the effects of a previously uncharacterized drug upon oral administration to experimental animals. Your tests involve examination of the effects of this compound within the gut following inducement of colitis-like symptoms. You find that administration of the drug to these animals leads to a reduction in the severity of inflammation in the gut and enhances a return to normal GI activity. Your test compound is most likely inducing the synthesis of which of the following compound?

Question

Quizplus · Accepted Answer

The Answer is B
EXPLANATION: The lipoxin, LXA₄, inhibits polymorphonuclear leukocyte (PMN) chemotaxis, PMN-mediated increases in vasopermeability, and PMN adhesion and migration through the endothelium resulting in an attenuation of pro-inflammatory responses in the gut. LXA₄ also stimulates phagocytosis of apoptotic PMN by monocyte-derived macrophages, which represents the resolution phase of inflammatory events.

You Are Studying the Effects of a Previously Uncharacterized Drug