You are studying the effects of mineral depletion in laboratory mice. These mice are fed a chow lacking in the trace metal zinc for a period of 2 weeks. Analysis of neurotransmitter levels and function at this time indicates that GABA production is significantly reduced. Which of the following symptoms is most likely to be observed in these mice as a result of the effects of the zinc restricted diet?

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Quizplus · Accepted Answer

Zinc deficiency can lead to reduced GABA production, which is an inhibitory neurotransmitter. This reduction can result in increased excitatory activity in the nervous system, leading to symptoms such as heightened excitability or seizures. The amino acid derivative, g-aminobutyrate (GABA) is a major inhibitor of presynaptic transmission in the CNS, and also in the retina. Neurons that secrete GABA are termed GABAergic. The activity of GAD requires pyridoxal phosphate (PLP) as a cofactor. PLP is generated from the B₆ vitamins through the action of pyridoxal kinase. Pyridoxal kinase itself requires zinc for activation. A deficiency in zinc or defects in pyridoxal kinase can lead to seizure disorders, particularly in seizure-prone preeclamptic patients (hypertensive condition in late pregnancy)

You Are Studying the Effects of Mineral Depletion in Laboratory