During a clinical study, an investigator examines the effects of monoamine oxidase inhibitors to treat certain types of major depressive and phobic anxiety disorders. The concentration of which of the following compounds is most likely to be increased as a result of this treatment?

Question

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Monoamine oxidase inhibitors (MAOIs) prevent the breakdown of monoamines, such as epinephrine, leading to increased levels of these neurotransmitters in the brain.  Epinephrine and norepinephrine are catabolized to inactive compounds through the sequential actions of catecholamine-O-methyltransferase (COMT) and monoamine oxidase (MAO). Compounds that inhibit the action of MAO have been shown to have beneficial effects in the treatment of clinical depression and anxiety disorders.

During a Clinical Study, an Investigator Examines the Effects of Monoamine