Patients with functional dyspepsia and prominent nausea frequently experience spurts of excessive gastric acid exposure to the proximal duodenum. This results in increased pancreatic secretion, mainly through the action of which of the following substances?

Question

Quizplus · Accepted Answer

Secretin is released in response to acidic chyme entering the duodenum and stimulates the pancreas to secrete bicarbonate-rich fluid to neutralize the acid. Acidification of the duodenal lumen triggers mechanisms to inhibit gastric acid production. Under low pH conditions duodenal enteroendocrine S cells release secretin which inhibits the release of gastrin from stomach antrum enteroendocrine G cells. The strongest stimulator for the release of secretin from S cells is contact with acidic chyme. Increased serum secretin levels stimulate water and alkali secretions from the pancreas and the hepatic ducts and inhibit gastrin release.

Patients with Functional Dyspepsia and Prominent Nausea Frequently Experience Spurts