Renin is released from the kidneys in response to a drop in blood pressure. The function of renin is to generate angiotensin I, which is accomplishes by which of the following mechanisms?

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Quizplus · Accepted Answer

Renin acts as an enzyme that cleaves angiotensinogen, a precursor protein in the blood, to form angiotensin I.  The intrarenal baroreceptor system is a key mechanism for regulating renin secretion. A drop in pressure results in the release of renin from the juxtaglomerular cells of the kidneys. The only function for renin is to cleave a 10-amino-acid peptide from the N-terminal end of angiotensinogen circulating in the blood. This proteolytic reaction generates angiotensin I.

Renin Is Released from the Kidneys in Response to a Drop