A Client Taking Protease Inhibitors for HIV Treatment Wants to Take

A client taking protease inhibitors for HIV treatment wants to take the supplement St. John's wort. What should the nurse reply to this client?

A) "St. John's Wort has been used to promote satiety."
B) "Take this supplement 1 hour after the protease inhibitor."
C) "St. John's Wort neutralizes the effects of damage to cells."
D) "This supplement has been shown to decrease the effects of protease inhibitors."