Development of which cell type is impaired in DiGeorge syndrome?
I- T cells
II- B cells
III- NK cells
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question

Development of which cell type is impaired in DiGeorge syndrome? 
I- T cells
II- B cells
III- NK cells
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Quizplus · Accepted Answer

DiGeorge syndrome affects thymic function. Therefore, T cell development is impaired. In Nezelof syndrome, patients may lack functional adenosine deaminase (ADA) enzymes, which leads to impaired development of all three cell types, but ADA enzymes are functional in DiGeorge syndrome.

Development of Which Cell Type Is Impaired in DiGeorge Syndrome