In Goodpasture syndrome, antigens that are normally sequestered are exposed, and antibodies are produced that react with those antigens. What is a potential factor that could lead to exposure of these normally hidden self-antigens?
I. Toxins
II. Infection
III. Smoking
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question

In Goodpasture syndrome, antigens that are normally sequestered are exposed, and antibodies are produced that react with those antigens. What is a potential factor that could lead to exposure of these normally hidden self-antigens? 
I. Toxins
II. Infection
III. Smoking
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Quizplus · Accepted Answer

All of these factors may contribute to the exposure of sequestered antigens, namely type IV collagen, and destruction of basement membrane in the lungs and kidneys.

In Goodpasture Syndrome, Antigens That Are Normally Sequestered Are Exposed