A KOH preparation of respiratory secretions of a 78-year-old man reveals large, spherical, thick-walled yeast cells 8 to 15 µm in diameter, usually with a single bud that is connected to the parent cell by a broad base.Which fungus will likely be isolated from the culture?

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The diagnosis of blastomycosis may easily be made when a clinical specimen is observed by direct microscopy. Blastomyces dermatitidis appears as large, spherical, thick-walled yeast cells 8 to 15 μm in diameter, usually with a single bud that is connected to the parent cell by a broad base.

A KOH Preparation of Respiratory Secretions of a 78-Year-Old Man