The presence of large, round or oval, multiply budding yeast cells, which resemble a "mariner's wheel," detected on direct microscopic examination usually indicates infection with

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Large, round or oval, multiply budding yeast cells (8 to 40 μm in diameter) are usually recognized in sputum, mucosal biopsy, and other exudates from patients infected with Paracoccidioides brasiliensis. Characteristic multiply budding yeast forms resemble a "mariner's wheel." The yeast cells surrounding the periphery of the parent cell range from 8 to 15 μm in diameter. Some cells may be as small as 2 to 5 μm but still exhibit multiple buds.

The Presence of Large, Round or Oval, Multiply Budding Yeast