How Is Sickle Cell Trait Different from Sickle Cell Disease

How is sickle cell trait different from sickle cell disease?

A) People with sickle cell disease are homologous for the mutation, whereas those with sickle cell trait are heterozygous for the mutation.
B) People with sickle cell trait are homologous for the mutation, whereas those with sickle cell disease are heterozygous for the mutation.
C) Sickle cell disease results from an inherited mutation, and sickle cell trait results from an acquired mutation.
D) Sickle cell trait results from an inherited mutation, and sickle cell disease results from an acquired mutation.