CAMP Stimulates Hormone Production and Cell Proliferation in Many Endocrine

cAMP stimulates hormone production and cell proliferation in many endocrine tissues, including the thyroid gland.Therefore, a type of somatic mutation that is most likely to lead to the formation of a hormone-overproducing benign tumor in the thyroid gland (a "toxic nodule") is one that causes:

A) Inability of the Gs protein to hydrolyze its bound guanosine triphosphate (GTP) .
B) Inability of the Gi protein to hydrolyze its bound GTP.
C) Inability of the protein kinase A regulatory subunits to respond to cAMP.
D) Absence of the CREB protein.
E) Degeneration of the thyroid-stimulating hormone (TSH) -producing thyrotrophs in the anterior pituitary gland.