The fat-soluble vitamin that is responsible for synthesis of blood-clotting factors by the liver is vitamin:

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Vitamin K is responsible for the synthesis of blood-clotting factors by the liver. It is a fat-soluble vitamin that is essential for the production of prothrombin and other clotting factors in the blood. Vitamin A is important for vision and immune system function, while vitamin D is important for calcium absorption and bone health. Vitamin E is an antioxidant that protects cells from damage. However, none of these vitamins are directly involved in blood clotting.

The Fat-Soluble Vitamin That Is Responsible for Synthesis of Blood-Clotting