A 4-year-old child was diagnosed with nephroblastoma,a kidney tumor.Subsequent genetic analysis of the child showed the presence of a mutation in a gene known to be associated with the development of this tumor but having a required role in renal development.What gene is it?

Question

Quizplus · Accepted Answer

Nephroblastoma or Wilms' tumor is associated with mutations in the WT1 gene, which is a tumor suppressor gene that plays a critical role in the development of the kidneys. The mutation in this gene disrupts the normal development of the kidney and leads to the development of the tumor. The other genes listed do not have a known association with the development of nephroblastoma.

A 4-Year-Old Child Was Diagnosed with Nephroblastoma,a Kidney Tumor