Which of the Following Are Problems Associated with Patient Use

Which of the following are problems associated with patient use of an MDI?
1) Failure to coordinate inhalation and actuation of the inhaler
2) A too-rapid inspiratory flow rate
3) Failure to shake and mix canister contents
4) Cessation of inspiration as the aerosol strikes the throat

A) 1 and 2 only
B) 2 and 3 only
C) 1,2,and 3 only
D) 1,2,3,and 4