In severe intravascular hemolysis, synthesis of this protein may not be sufficient to what is being used to transport hemoglobin to the liver.

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In severe intravascular hemolysis, red blood cells are rapidly destroyed and hemoglobin is released into the bloodstream. Haptoglobin binds to free hemoglobin and helps transport it to the liver for breakdown and excretion. However, in severe hemolysis, the production of haptoglobin may not be sufficient to keep up with the amount of hemoglobin being released, leading to decreased levels of haptoglobin in the blood. This is why B (haptoglobin) is the best choice.

In Severe Intravascular Hemolysis, Synthesis of This Protein May Not