A laboratory professional is reviewing blood smears, and notices moderate spherocytes on one patient.What appropriate follow-up test would help determine the etiology of these cells?

Question

Quizplus · Accepted Answer

Moderate spherocytes are commonly associated with autoimmune hemolytic anemia (AIHA). The direct antiglobulin test (DAT) is the appropriate follow-up test to determine the etiology of spherocytes in this case. The DAT detects the presence of antibodies or complement proteins on the surface of red blood cells, indicating immune-mediated hemolysis. MCV, hemoglobin electrophoresis, and unconjugated bilirubin levels are not specifically related to spherocytes or AIHA.

A Laboratory Professional Is Reviewing Blood Smears, and Notices Moderate