A patient has been confirmed with B cell ALL.Confirmation of ALL subtype has been inconclusive based on the tests conducted.Immunophenotyping has been ordered as a last means of confirming the subtype.Which markers would be ideal to help differentiate Pre-B cell ALL from Pro-B cell ALL?

Question

Quizplus · Accepted Answer

CD10 is a marker for Pre-B lymphoblasts, while Pro-B lymphoblasts are typically CD34+CD19+. CD20 is not typically expressed on ALL cells. Therefore, CD10 is the most ideal marker for distinguishing Pre-B cell ALL from Pro-B cell ALL.

A Patient Has Been Confirmed with B Cell ALL