Name the genetic mutation that induces increased concentration of prothrombin in the circulation that leads to increased risk of venous thrombosis.

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The genetic mutation that induces increased concentration of prothrombin in the circulation that leads to increased risk of venous thrombosis is a G → A substitution on nucleotide 20210 of the prothrombin gene. This mutation is found in the 3’-untranslated region of the prothrombin gene and results in increased mRNA stability and gene expression, leading to increased levels of prothrombin in the plasma.

Name the Genetic Mutation That Induces Increased Concentration of Prothrombin