Immunophenotyping is essential for the diagnosis of ALL, separation of T and B lineage ALL, and identification of subtypes of B lineage ALL.What markers can blasts express in precursor B cell ALL?

Question

Quizplus · Accepted Answer

Precursor B cell ALL blasts commonly express the markers CD10 and TdT. CD10 is a marker of early B cell development, while TdT is an enzyme involved in V(D)J recombination and is expressed in immature lymphoid cells. Therefore, immunophenotyping with CD10 and TdT antibodies is important for the identification of B lineage ALL.

Immunophenotyping Is Essential for the Diagnosis of ALL, Separation of T