What Defines the FDA's De Minimis Rule

What defines the FDA's de minimis rule?

A) A requirement that the least toxic food additive be used on foods
B) The minimum amount of a food particle that can be detected
C) The minimum amount of nitrite that can be added to foods to prevent spoilage over a certain time frame
D) The amount of a food additive that causes no more than a one-in-a-million lifetime risk of cancer to human beings
E) The amount of a food additive that causes no more than a one-in-a-million risk of birth defects in human beings