Why is meperidine (Demerol) not recommended for children in sickle cell crisis?
A) May induce seizures
B) Is easily addictive
C) Not adequate for pain relief
D) Given by intramuscular injection

Question

Quizplus · Accepted Answer

A metabolite of meperidine, normeperidine, is a central nervous system stimulant that produces anxiety, tremors, myoclonus, and generalized seizures when it accumulates with repetitive dosing. Patients with sickle cell disease are particularly at risk for normeperidine-induced seizures. Meperidine is no more addictive than other narcotic agents. Meperidine is adequate for pain relief. It is available for IV infusion.

Why Is Meperidine (Demerol) Not Recommended for Children in Sickle