What selective agent has resulted in heterozygote advantage for thalassemia mutation carriers?

Question

Quizplus · Accepted Answer

Falciparum malaria has been the selective agent that has resulted in heterozygote advantage for thalassemia mutation carriers. The carriers have a lower chance of developing severe malaria, which has benficial effects in malaria-endemic regions. Therefore, the allele frequency of thalassemia mutations is higher in these regions.

What Selective Agent Has Resulted in Heterozygote Advantage for Thalassemia