The topology of membrane proteins can often be predicted by computer programs that identify_____ topogenic segments.

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The topology of membrane proteins can often be predicted by identifying hydrophobic topogenic segments. These segments consist of regions of the protein that are soluble in nonpolar solvents and are responsible for anchoring the protein in the lipid bilayer of the membrane. The hydrophilic segments, on the other hand, are water-soluble and face either the extracellular or cytoplasmic environment. Glycosylation-specific and cleavable signal sequences are not necessarily indicative of membrane protein topology.

The Topology of Membrane Proteins Can Often Be Predicted by Computer