Before ligand binding,receptor tyrosine kinases:
A)contain binding sites for SH2-domain containing proteins.
B)contain activation lip tyrosines within the kinase active site.
C)bind to GRB2 within the cytosolic domains.
D)have excellent tyrosine kinase activity.

Question

Quizplus · Accepted Answer

Receptor tyrosine kinases (RTKs) contain activation lip tyrosines within the kinase active site that need to be phosphorylated to activate their kinase activity. Ligand binding induces dimerization of RTKs, which brings the two kinase domains in close proximity, allowing them to trans-phosphorylate each other's activation lip tyrosines and activate their kinase activity. Before ligand binding, RTKs are in an inactive state. They may contain binding sites for SH2-domain containing proteins and can bind to GRB2 within the cytosolic domains, but these are not unique features of inactive RTKs.

Before Ligand Binding,receptor Tyrosine Kinases