By what mechanism does PI-3 phosphate promote activation of protein kinase B (PKB)?
A)recruiting PKB to the plasma membrane
B)recruiting the activating kinase PDK1 to the plasma membrane
C)releasing inhibition of the catalytic site by the PH domain
D)the first and second answers are correct
E)all of the above

Question

Quizplus · Accepted Answer

PI-3 phosphate promotes the activation of protein kinase B (PKB) by recruiting PKB to the plasma membrane, recruiting the activating kinase PDK1 to the plasma membrane, and releasing inhibition of the catalytic site by the PH domain. All these mechanisms work together to facilitate the activation of PKB.

By What Mechanism Does PI-3 Phosphate Promote Activation of Protein