Which of the following explains why Ras is activated quickly by RTKs?
A)RTKs phosphorylate Ras.
B)Ras changes conformation upon ligand binding to prepare for activation.
C)Ras binds phosphotyrosine residues on RTKs.
D)Ras is maintained at the plasma membrane through a lipid-mediated attachment.

Question

Quizplus · Accepted Answer

Ras is maintained at the plasma membrane through a lipid-mediated attachment, which allows it to quickly interact with RTKs (Receptor Tyrosine Kinases) upon their activation. This proximity to RTKs facilitates its rapid activation. Ras itself is not directly phosphorylated by RTKs, nor does it bind phosphotyrosine residues on RTKs. Its activation involves the exchange of GDP for GTP, which is catalyzed by guanine nucleotide exchange factors (GEFs) activated by RTK signaling.

Which of the Following Explains Why Ras Is Activated Quickly