Which disease results from deletion of the $\beta$-globin gene cluster LCR?
A)Sickle-cell disease
B)Mild $\beta$-thalassemia.
C)Severe$\alpha$-thalassemia.
D)Mild $\beta$-thalassemia
E)Severe $\beta$-thalassemia

Question

Quizplus · Accepted Answer

Deletion of the F1F1F1S1βF1F1F10-globin gene cluster LCR results in the absence of β-globin chains, leading to severe β-thalassemia. Mild forms of β-thalassemia result from mutations that affect β-globin production without completely eliminating it, whereas α-thalassemia results from deletions or mutations affecting the α-globin gene cluster. Sickle-cell disease is caused by a point mutation affecting the β-globin gene, and not by deletion of the LCR.

Which Disease Results from Deletion of The β\betaβ -Globin Gene Cluster LCR? A)Sickle-Cell Disease B)Mild

Which Disease Results from Deletion of The $\beta$ -Globin Gene Cluster LCR?
A)Sickle-Cell Disease
B)Mild