Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?
A)Segmental duplications are inherently repetitive.
B)Segmental duplications contain large numbers of LINEs,which interfere with sequence annotation.
C)Segmental duplications interfere with BLAST analysis.
D)Segmental duplications are often found in areas of constitutive heterochromatin.

Question

Quizplus · Accepted Answer

Segmental duplications are regions in the genome where identical or nearly identical sequences are present in two or more locations. These duplications can be extensive, covering many kilobases or even megabases of DNA. Because of this repetitive nature of the sequence, it becomes challenging to align reads and performing genome assembly. This results in gaps or assemblies with errors, which prevents researchers from accurately determining the structure and function of the genome.

Why Do Segmental Duplications Pose a Logistical Challenge in the Proper