Why is phosphorylation-dephosphorylation commonly used to regulate signal transduction pathways? A)Phosphate groups are efficient second messengers. B)Protein kinases and phosphatases are abundant in most cells. C)The hydrolysis of bound GTP results in GDP and P_i. D)The addition or removal of a phosphate group can expose or hide potential binding sites in proteins.

Question

Quizplus · Accepted Answer

The addition or removal of a phosphate group can introduce or remove a negative charge, which can lead to conformational changes that expose or hide potential binding sites in proteins. This makes phosphorylation-dephosphorylation an efficient way to modulate the activity of signaling proteins in signal transduction pathways. The other options (A, B, and C) are not completely accurate or relevant to the question.

Why Is Phosphorylation-Dephosphorylation Commonly Used to Regulate Signal Transduction Pathways