Question 1

Some patients suffering from bare lymphocyte syndrome (BLS; a rare immunodeficiency) have a genetic mutation in their TAP1/TAP2 genes causing the production of a defective TAP transporter. Describe what effect this has on antigen processing and in what cells.

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Question 2

Yersinia enterocolitica is an example of a bacterium that can outsmart the adaptive immune system by inhibiting proinflammatory cytokine production signal transduction pathways. Give one example of another microbe that can outsmart this system and discuss why this is of benefit from the microbial perspective.

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Question 3

List the steps for the classical complement cascade. Discuss two ways this cascade results in microbial destruction.

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Question 4

Why are antihistamines good for allergic rhinitis but NOT for atopic asthma?

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Question 5

X-linked hyper IgM syndrome (XHIM) is an immunodeficiency disorder caused by mutations of the gene encoding CD154. Why is this disease characterized by recurrent infections (starting in childhood) and elevated serum levels of IgM?

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Question 6

Based on the Special Topic reading 24.1, would taking probiotic health supplements be good for your immunity?

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Question 7

Would treating a person infected with HIV that has recently developed AIDS using a helper T-cell transfusion work? Why or why not?

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Question 8

A patient presents in the emergency room with large red lesions up and down his arms. His case history reveals that he works for a gardening company and this rash most likely developed after clearing a weedy bank two days prior. The resident on duty concludes that the rash is due from poison ivy exposure. Immunologically speaking what is going on in this man's body and what type of immune response is he experiencing?

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Question 9

If a person was unable to undergo negative selection during T-cell education, what is T-cell education and why would this be a severe immune problem?

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Question 10

Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disorder affecting the skin, joints, kidneys, and other organs. A hallmark of lupus is the production of an array of autoantibodies. Some scientists believe that the autoantibody formation seen in lupus is a result of Epstein-Barr virus (EBV) molecular mimicry. What do these scientists believe has happened in the case of lupus? Give one example as evidential support.

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Quiz 24: The Adaptive Immune Response