Prader-Willi and Angelman syndromes both arise from the same area of chromosome 15,illustrating

Question

Quizplus · Accepted Answer

Prader-Willi and Angelman syndromes both arise from the same area of chromosome 15 due to genomic imprinting. Genomic imprinting is an epigenetic phenomenon where certain genes are expressed based on their parental origin, in a process that is independent of the DNA sequence. This means that some genes are silenced or active depending on whether they are inherited from the mother or the father. In Prader-Willi syndrome, the paternal copy of the critical region on chromosome 15 is missing or inactive, while in Angelman syndrome, the maternal copy is affected. This results in different symptoms and clinical presentations for each disorder.

Prader-Willi and Angelman Syndromes Both Arise from the Same Area