The most common form of severe combined immunodeficiency disease results from an X-linked mutation in the gene that codes for:

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The most common form of severe combined immunodeficiency disease (SCID) is caused by a mutation in the X-linked gene that codes for the gamma chain subunit (also known as CD132) of the receptor for interleukins-2, -4, -7, -9, -15, and -21. This receptor is shared by lymphocytes and is involved in signaling for the development and function of T and B cells. Without this receptor, the immune system cannot mount a proper response to infections.

The Most Common Form of Severe Combined Immunodeficiency Disease Results