Question 1

The high-sensitivity detection method for CRP (hs-CRP)used to detect low concentrations of this protein is typically a(n):

Accepted Answer

The answer of The high-sensitivity detection method for CRP (hs-CRP)used...

Question 2

In addition to unesterified cholesterol,what is the second constituent of the outer coating of a lipoprotein,labeled with a question mark and represented by a white circle in this diagram?

Accepted Answer

The second constituent of the outer coating of a lipoprotein, labeled with a question mark and represented by a white circle in the diagram, is a phospholipid.

Question 3

Approximately one-third of the daily production of circulating cholesterol is converted in the liver to form:

Accepted Answer

Approximately one-third of the daily production of circulating cholesterol is converted in the liver to form bile acids.

Question 4

What is (are)the principal apo B-100 containing lipoprotein(s)secreted by the liver?

Accepted Answer

VLDL (Very Low-Density Lipoprotein) is the principal apo B-100 containing lipoprotein secreted by the liver. LDL (Low-Density Lipoprotein) is derived from VLDL in the bloodstream, not directly secreted by the liver.

Question 5

Which one of the following lipid metabolic pathways involves the removal of excess cellular cholesterol from cells and returning it to the liver for excretion?

Accepted Answer

Reverse-cholesterol transport is the pathway that involves the removal of excess cellular cholesterol from cells and returning it to the liver for excretion. This pathway is important in preventing the accumulation of cholesterol in peripheral tissues, which can lead to the development of atherosclerosis. The other options (A, B, and C) are not involved in this specific pathway.

Question 6

A 9-year-old boy was referred by his dermatologist for a lipid evaluation after the boy developed what appeared to be a raised yellowish rash over his palms and elbows.The boy had no previous history of heart problems and no family history of any coronary disorders.However,when he was 8,he did have two acute attacks of pancreatitis and abdominal pain.His lipid workup is as follows (specimen was a fasting blood draw): triglyceride 3200 mg/dL (normal <200 mg/dL),total cholesterol 190 mg/dL (normal <200 mg/dL),glucose 160 mg/dL (normal 60 to 110 mg/dL).His HDL concentration was in normal range,but LDL was elevated.Specimen was grossly lipemic.What is the likely cause of these symptoms?

Accepted Answer

The high triglyceride levels in the presence of a normal HDL concentration and elevated LDL suggest a disorder of lipoprotein metabolism. The grossly lipemic specimen also supports this. The acute attacks of pancreatitis and abdominal pain at age 8 are also suggestive of pancreatic involvement. Lipoprotein lipase deficiency is a rare genetic disorder that leads to high levels of triglycerides and low levels of HDL due to impaired hydrolysis of TG-rich lipoproteins. This disorder can manifest in childhood, as seen in this case. Familial hypercholesterolemia and genetic deficiency of LDL are unlikely given the patient's lipid profile. Tangier disease is also unlikely given the absence of corneal opacities or orange tonsils, and the presentation of a raised yellowish rash over the patient's palms and elbows.

Question 7

The Friedewald formula is used to indirectly determine the concentration of which one of the following?

Accepted Answer

The Friedewald formula is used to indirectly determine the concentration of LDL cholesterol.

Question 8

In the intracellular-cholesterol transport pathway of lipoprotein metabolism,cholesterol homeostasis is maintained through control of cellular uptake.The LDL cell surface receptor delivers lipoprotein particles containing cholesteryl esters to lysosomes.The apolipoprotein that is recognized by this receptor is apo:

Accepted Answer

The LDL cell surface receptor recognizes apolipoprotein B-100 (apoB-100) on lipoprotein particles containing cholesteryl esters and delivers them to lysosomes for cholesterol processing. ApoE and apoC-II are recognized by other receptors in lipoprotein metabolism, but they do not contribute to intracellular cholesterol transport via the LDL receptor. ApoA2 is not a component of LDL particles.

Question 9

The major component of a lipoprotein that functions to maintain the structural integrity of the lipoprotein complex and that modulates the activity of the enzymes that act on lipoproteins is the:

Accepted Answer

Apolipoprotein is the major component of a lipoprotein that functions as a structural component and also modulates the activity of the enzymes that act on lipoproteins. Phospholipids are important for stabilizing the structure of the lipoprotein, but they do not modulate enzyme activity. The lipid core contains the majority of the lipids in a lipoprotein, but it does not have a structural role or modulate enzyme activity. Lipoprotein lipase is an enzyme that acts on lipoproteins, but it is not a component of the lipoprotein itself.

Question 10

You have received two blood samples,one in a sodium citrate tube for coagulation studies and the other in an oxalate tube for glucose analysis from a patient diagnosed with diabetes mellitus.This patient's physician contacts you to request that lipid and lipoprotein analyses be added to the previous studies.What would be the best blood specimen for lipoprotein analyses and why?

Accepted Answer

Serum would be the most appropriate choice for lipoprotein analysis because it does not contain anticoagulants or additives that may interfere with the analysis and current cut points are based on serum values. Additionally, serum does not have osmotic effects on cells, unlike anticoagulated plasma, which may cause hemolysis and release of intracellular contents that interfere with lipid and lipoprotein analysis.

Quiz 23: Lipids, lip-Oproteins, apolipoproteins, and Other Cardiac Risk Factors

The high-sensitivity detection method for CRP (hs-CRP) used to detect low concentrations of this protein is typically a(n) :

In addition to unesterified cholesterol,what is the second constituent of the outer coating of a lipoprotein,labeled with a question mark and represented by a white circle in this diagram?

Approximately one-third of the daily production of circulating cholesterol is converted in the liver to form:

What is (are) the principal apo B-100 containing lipoprotein(s) secreted by the liver?

Which one of the following lipid metabolic pathways involves the removal of excess cellular cholesterol from cells and returning it to the liver for excretion?

The Friedewald formula is used to indirectly determine the concentration of which one of the following?

The major component of a lipoprotein that functions to maintain the structural integrity of the lipoprotein complex and that modulates the activity of the enzymes that act on lipoproteins is the: