Select the mechanism of action of the glucocorticoids in the suppression of the inflammatory response.
A) The glucocorticoid hormone, ACTH, is transported to the target cell. ACTH passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-ACTH complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
B) The glucocorticoid hormone, CRH, is transported to the target cell. CRH passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-CRH complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
C) The glucocorticoid hormone, cortisol, is transported to the target cell. Cortisol passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-glucocorticoid complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
D) None of these are correct.
Correct Answer:
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