Natural proteins most commonly contain linear polypeptides between 100 and 1000 residues in length.One of the reasons polypeptides outside this range may be disfavored is that
A)larger polypeptides would likely be insoluble.
B)smaller polypeptides do not form stable folded structures.
C)smaller polypeptides typically assemble into prion-like aggregates.
D)amide linkages are not strong enough to keep larger polypeptides intact.
E)ribosomes are unable to synthesize larger polypeptides.

Question

Quizplus · Accepted Answer

Smaller polypeptides may not have enough residues to form the stable folded structures needed for protein function. Larger polypeptides are not disfavored due to insolubility or inability to be synthesized by ribosomes, but rather due to the difficulty in maintaining precise folding and stability over a long chain. Amide linkages are strong enough to keep larger polypeptides intact. Prion-like aggregates are a potential issue for any polypeptide, regardless of size.

Natural Proteins Most Commonly Contain Linear Polypeptides Between 100 and 1000