In the reaction catalyzed by pyruvate carboxylase (the first reaction in gluconeogenesis),CO₂ is

Question

Quizplus · Accepted Answer

Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate, which is the first step in the gluconeogenesis pathway. The reaction is dependent on the presence of ATP and the cofactor biotin, which become covalently attached to the enzyme during the reaction. Therefore, choice B is the correct answer as ATP energizes the reaction. Choice A is incorrect because there is no mention of CO₂ being lost from oxaloacetate in the reaction. Choice C is incorrect because NADH is not involved in the reaction catalyzed by pyruvate carboxylase. Choice D is incorrect because phosphoenolpyruvate is not a substrate or product of the pyruvate carboxylase reaction.

In the Reaction Catalyzed by Pyruvate Carboxylase (The First Reaction