Which protein will be phosphorylated in a muscle cell in an obese individual with elevated serum levels of free fatty acids?
A) protein kinase C
B) insulin receptor
C) IRS1
D) GLUT1

Question

Quizplus · Accepted Answer

Elevated serum levels of free fatty acids can lead to insulin resistance in muscle cells, which can result in reduced activation of IRS1, a protein involved in insulin signaling. Reduced activation of IRS1 can lead to decreased glucose uptake and increased glucose production in the liver. Phosphorylation of IRS1 due to decreased activation can further exacerbate insulin resistance, making it the most likely protein to be phosphorylated in this scenario. Protein kinase C is involved in insulin signaling, but its phosphorylation would not be directly impacted by elevated serum levels of free fatty acids. The insulin receptor is necessary for insulin signaling to occur but would not necessarily be the target of phosphorylation. GLUT1 is a glucose transporter and would not likely be directly impacted by elevated serum levels of free fatty acids.

Which Protein Will Be Phosphorylated in a Muscle Cell in an Obese