What might be the outcome of a mutation that causes the adiponectin receptor to be constitutively activated?
A) very low levels of GLUT4 in muscle cell membranes
B) high levels of acetyl-CoA carboxylase activity
C) insulin resistance
D) highly activated AMPK

Question

Quizplus · Accepted Answer

Adiponectin receptors are known to enhance insulin sensitivity by increasing glucose uptake in muscle and decreasing hepatic glucose production. Constitutive activation of the receptor could lead to constant stimulation of downstream signaling pathways, eventually leading to insulin resistance.

Answer: D
 AMPK is a protein kinase that plays a crucial role in cellular energy metabolism. Adiponectin receptors activate AMPK, and the constitutive activation of the receptor would result in highly activated AMPK, leading to increased glucose uptake in muscle and decreased hepatic glucose production.

What Might Be the Outcome of a Mutation That Causes